The effect of hydroxyapatite and growth factors on reparative dentine formation in the therapy of injured pulp

Background/Aim. The studies of hydroxyapatite (HAp) and growth factors as the materials used for direct pulp capping have produced conflicting results both issue inflammatory response calcified bridge formation. Hap/poly (lactide-co-glycolide) (HAp/PLGA) is a bioresorbable polymer with demonstrated good characteristics carrier bone morphogenetic protein necessary in tissue regeneration. role dental reparation (in reactionary reparative dentinogenesis) represents new foundation provides different approach to treatment. Growth ? transforming factor beta-1 (TGF-?-1) directly induce morphological functional differentiation neo-odontoblasts. aim this study was investigate effect calcium HAp/PLGA (TGF ?-1) formation dentine on teeth our experimental model. Methods. In study, rodent (rabbit) were animal After trepanation space sterile steel drills, capped (experimental group I; n = 60); combined TGF ?-1 II; 60), there control intact (n 20). experiment performed general anesthesia. animals kept alive 1, 3, 6 months. extracted adequately prepared scanning electron microscopy. Results. Scanning microscopy that number form bridges HAp/PLGA+TGF group, months after treatment, statistically significantly greater (66.67%) than 3 (26.67%), at statistical significance level p < 0.05. Conclusion. Direct covers artificially exposed makes possible (a tubular structure composed dentine) period